An enzyme that fights against autoimmune diseases

An enzyme that fights against autoimmune diseases

Autoimmune diseases are referred as abnormal human body immune responses to substances or tissues that are found in the body. Many medication methods are employed to suppress the immune responses of our bodies. This process is known as immune suppression.

Some autoimmune diseases that occur in us are scleroderma, vitiligo, rheumatoid arthritis, psoriasis, inflammation of thyroid glands etc. It is generally said that the causes responsible for these autoimmune diseases were not known. But there is always some thought that these diseases might be caused due to chemicals, environmental factors or virus etc.

The latest news is that an enzyme is found to be responsible for the autoimmune diseases. As per the reports of UT South-western medical centre, activating a particular enzyme leads to two autoimmune diseases in mice. It was also found that when the same enzyme was inhibited, then the mice were safe.

Dr Zhijian Chan was of the opinion that enzyme cGAS was responsible for autoimmune diseases such as Aicardi-Goutieres Syndrome, AGS , Systemic Lupus Erythematosus, SLE etc. So when the enzyme cGAS was inhibited then the above said diseases got suppressed. It was also said that in autoimmune diseases, immune system turns against our body and do not protect the body.

It is known that AGS affect the brain part and is very rare genetic disorder. SLE is known to affect parts such as joints, skin, kidneys etc. It was also said that both the diseases cannot be totally cured but could be controlled. High resolution structures developed in the recent times should pave way for the inhibitors of cGAS types.

It was also said that the research team did some research activities using genetically engineered mice not having DNase- 2.It was found that the inability to degrade lysosome Deoxyribo nucleic acid caused severe autoimmunity in these mice. The condition was brought back to normal by inhibiting the enzyme cGAS.  The entire study got published in the journal Proceedings of the National Academy of Sciences, PNAS.


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